Spring 2017 update from Chordoma UK and Professor Adrienne Flanagan
During the past 24 months, much has been achieved. We
have compiled over 400 samples of chordoma from patients across the UK. Contributions
have also been made from afar including Slovenia. This represents the largest
collection of chordoma samples in the world.
Tissue microarrays have been made from these samples and are available
for research purposes.
documentation of the behavior of the disease has been made of more than 60
patients and this will be used as a model for building a network across the
UK. In the first instance we have
established close links with Mr David Choi, a leading neurosurgeon in the
National Hospital for Neurology and Neurosurgery, Queen Square, London. Thanks to Chordoma UK we have been able to employ the UK's first Chordoma patient and biobank coordinator. This important role is now one year old and Chordoma UK has agreed to continue this support for a further 2 years.
are currently exploiting the wonderful opportunity that the 100,000 Genomes Project
provides including patients with chordoma in this study. https://www.genomicsengland.co.uk/the-100000-genomes-project/
published paper in The Journal of
Pathology on the impact of EGFR inhibitors has contributed to the pending
first randomized clinical trial for chordoma. Funding for this important research through Chordoma UK.
Scheipl S, Barnard M, Cottone
L, Jorgensen M, Drewry D, Zuercher WJ, Turlais F, Ye H, Leite AP, Smith JA,
Leithner A, Möller P, Brüderlein S, Guppy N, Amary F, Tirabosco R, Strauss SJ,
Pillay N, Flanagan AM. (2016) EGFR
inhibitors Identified as a Potential Treatment for Chordoma in a Focused
Compound Screen. J Pathol. Apr 22;239(3): 320-334.
The funding that was provided
from Chordoma UK to develop a new test for detecting the tumour signature in
the blood of patients with chordoma has revealed that in some patients this has
been successful. A larger study is required to establish if this can be
introduced into routine clinical practice to monitor patients with chordoma. We
have been collecting samples from patients for the last 2 years and this can
now be used to expand the study.
We have recently been awarded
£25,000 to study the role of brachyury in chordoma.
All research including data
UCL/UCLH Biobank for Studying Health and Disease. REC
IRAS project ID:183090