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New funding for research into Chordoma

Dr Inga Usher, funded by Chordoma UK, has won £10,000 from the Pathological Society of Great Britain and Ireland to carry out research into chordoma. Her project entitled “Exploring the functional impact of the chordoma-associated rs2305089 single nucleotide polymorphism” uses an in vitro cancer model and genome editing technology to find out what the rs2305089 genetic variant in brachyury does. Our previous research has shown that nearly all people with a chordoma carry this variant from birth, that is it is very unlikely to develop a chordoma without this genetic variant. However, as nearly half of the unaffected European population has this variant something else is required to bring about the development of the tumour. At present the function of the genetic variant has yet to be understood and this is what Inga’s project hopes to shed light on.

Inga is carrying out this research as part of her Medical Doctorate at the UCL Cancer Institute under the supervision of Professor Adrienne Flanagan.


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